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Several attempts were undertaken to circumvent this, such as the formulation of a GLP-1 tablet for buccal administration, which was found to improve glycemia in type 2 diabetes ( in vitro studies formed the basis for the hypothesis that DPP-4 inhibition may be a potential novel therapeutic agent to stabilize endogenously released GLP-1

Interestingly, this study also found that in cancer cell lines, telomere extension occurred through activation of the ALT (Alternative Lengthening of Telomeres) pathway rather than telomerase, suggesting cell-type-specific mechanisms